A higher %PLR measured at 0–24 h after hospital admission was related to good neurological outcomes at 3 months in post-cardiac arrest patients treated with TTM (SMD 0.87 95% confidence interval 0.70–1.05 I 2 = 0%). Standardized mean differences (SMDs) were calculated to compare patients with good or poor neurological outcomes. Results: A total of 618 patients from four studies were included in this study. For an assessment of the methodological quality of the included studies, two authors utilized the prognosis study tool independently. Material and Methods: We systematically searched MEDLINE, EMBASE, and the Cochrane Library (search date: 9 July 2021) for studies on post-cardiac arrest patients treated with TTM that had measured the percent constriction of pupillary light reflex (%PLR) with quantitative pupillometry as well as assessed the neurological outcome. Background and objectives: This study aims to evaluate the usefulness of the quantitative pupillary light reflex as a prognostic tool for neurological outcomes in post-cardiac arrest patients treated with targeted temperature management (TTM).

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